Abstract: Objective To investigate the polymorphism of the TPH gene T3792A locus in Han ethnic group of north China and its application value in forensic science. Methods The polymorphism of T3792A locus of the TPH gene was analyzed by the ASPCR of blood samples from 173 unrelated individuals of north Chinese Han population. Results The distribution of the T3792A locus polymorphism of the TPH gene in Han ethnic group of north China followed the Hardy-Weinberg law, with the allele A and T gene frequency of 0.486 and 0.514, respectively. Conclusion The TPH gene T3792A locus shows a very good genetic polymorphism, and may be applied to individual identification and paternity testing.

Key words: forensic genetics, polymorphism, single nucleotide, tryptophan hydroxylase, han ethnic group of north China