Research Progress of MALDI-TOF-IMS in Biomedicine and Its Application Prospect in Forensic Sciences

doi:10.3969/j.issn.1004-5619.2017.05.016

›› 2017, Vol. 33 ›› Issue (5): 522-525.DOI: 10.3969/j.issn.1004-5619.2017.05.016

Research Progress of MALDI-TOF-IMS in Biomedicine and Its Application Prospect in Forensic Sciences

REN GUAN-HENG1,2, WENG RONG-HUA3, SHI YAN1, HUANG PING1, LI ZHENG-DONG1, SHAO YU1, DENG KAI-FEI1, LIU NING-GUO1, CHEN YI-JIU1

1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China; 2. Department of Forensic Science, School of Basic Medicine Science, Southern Medical University, Guangzhou 510515, China; 3. Chengxiang Branch of Putian Public Security Bureau, Putian 351100, China

Online:2017-10-25 Published:2017-10-28

Abstract

Abstract: Matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry （MALDI-TOF-IMS） can analysis unknown compounds in sections and obtain molecule imaging by scanning biological tissue sections, which has become a powerful tool for the research of biomarker, lipid distribution and drug metabolism, etc. This article reviews the application of this technique in protein identification, clinical application, drug discovery, lipid research and brain injury.

Key words: forensic pathology, imaging mass spectrometry, review, matrix-assisted laser desorption, ionization

CLC Number:

DF795.1

REN GUAN-HENG, WENG RONG-HUA, SHI YAN, ET AL.. Research Progress of MALDI-TOF-IMS in Biomedicine and Its Application Prospect in Forensic Sciences[J]. , 2017, 33(5): 522-525.

[1]	Jin-ting LIU, Li-ying ZHOU, Jia-hong XIANG, Zi-yi LI, Wan-ting XIE, Ke-ming YUN, Yan SHI. Research Progress on Detection of New Psychoactive Substance Piperazines in vivo [J]. Journal of Forensic Medicine, 2024, 40(3): 276-283.
[2]	Wei FANG, Ji-long ZHENG, Yi-ming FU, Yi LIU. Research Progress of Using Canine Olfactory Search for Human Remains [J]. Journal of Forensic Medicine, 2024, 40(3): 269-275.
[3]	Nian-nian CHEN, Jiao-fang YU, Peng WU, Li LUO, Ya-qin BAI, Li-kai WANG, Xiao-qian LI, Zhan-peng LI, Cai-rong GAO, Xiang-jie GUO. Urine Metabolites Changes in Acute Myocardial Infarction Rats via Metabolomic Analysis [J]. Journal of Forensic Medicine, 2024, 40(3): 227-236.
[4]	Lei SHI, Ye XUE, Li-rong QIU, Ting LU, Fei FAN, Yu-chi ZHOU, Zhen-hua DENG. Research Progress on Dental Age Estimation Based on MRI Technology [J]. Journal of Forensic Medicine, 2024, 40(2): 112-117.
[5]	Shang-heng CHEN, Sheng-zhong DONG, Zhi-min WANG, Guang-hui HONG, Xing YE, Zi-jie LIN, Jun-yi LIN, Jie-qing JIANG, Shou-yu WANG, Han-cheng LIN, Yi-wen SHEN. Biomarkers Screening and Mechanisms Analysis of the Restraint Stress-Induced Myocardial Injury in Hyperlipidemia ApoE^-/- Mice [J]. Journal of Forensic Medicine, 2024, 40(2): 172-178.
[6]	Juan-juan WU, Jun-jie HUANG, Yu ZHANG, Jia-ying ZHUO, Gang CHEN, Shu-han YANG, Yun-qi ZHAO, Yan-yan FAN. Time-Dependent Sequential Changes of IL-10 and TGF-β1 in Mice with Deep Vein Thrombosis [J]. Journal of Forensic Medicine, 2024, 40(2): 179-185.
[7]	Dan-yang LI, Yu PAN, Hui-ming ZHOU, Lei WAN, Cheng-tao LI, Mao-wen WANG, Ya-hui WANG. Application of Medical Statistical and Machine Learning Methods in the Age Estimation of Living Individuals [J]. Journal of Forensic Medicine, 2024, 40(2): 118-127.
[8]	Yan-ru YAO, Jing JIN, Ying-jie WANG, Jin-zhuan ZHANG, Ying-zhe LI, Yong-xin XU. Research Progress on Biological Evidence Identification in Fire Scenes [J]. Journal of Forensic Medicine, 2024, 40(1): 64-69.
[9]	Wen-jing HU, Ting-ting YANG, Ya-ya WANG, Jiang-wei YAN. The Latest Research Progress on Cell-Free DNA and Prospects of Its Forensic Application [J]. Journal of Forensic Medicine, 2024, 40(1): 70-76.
[10]	Yun-hong XING, Yang LI, Wen-zheng WANG, Liang-liang WANG, Le-le SUN, Qiu-xiang DU, Jie CAO, Guang-long HE, Jun-hong SUN. Pathological Characteristics and Classification of Unstable Coronary Atherosclerotic Plaques [J]. Journal of Forensic Medicine, 2024, 40(1): 59-63.
[11]	Tian TIAN, Xin-biao LIAO, Fu ZHANG, Kai-fei DENG, Ji ZHANG, Ping HUANG, Yi-jiu CHEN, Jian-hua ZHANG. Forensic Pathological Diagnosis of Acute and Old Myocardial Infarction Using Fourier Transform Infrared Spectroscopy [J]. Journal of Forensic Medicine, 2023, 39(6): 535-541.
[12]	Bin YANG, Lu-yao XU, Ling-yue LI, Dong-fang QIAO, Si-hao DU, Xia YUE, Hui-jun WANG. Pathological Changes and Cause of Death Associated with the Global Novel Coronavirus Disease （COVID-19） [J]. Journal of Forensic Medicine, 2023, 39(6): 586-595.
[13]	Xin ZHAO, Zhi-ming CHEN, Wen-yun LIU, Bo WANG, Hong-yang LI, Li-yao YANG, Yan TENG, Li-jun WANG, Yan-bin GAO, Wei-long CHEN, Lei ZHANG. Application of Targeted Coronary Angiography in the Diagnosis of Sudden Cardiac Death [J]. Journal of Forensic Medicine, 2023, 39(6): 542-548.
[14]	Yi-hang HUANG, Wei-bo LIANG, Hui JIAN, Sheng-qiu QU. Modeling Methods and Influencing Factors for Age Estimation Based on DNA Methylation [J]. Journal of Forensic Medicine, 2023, 39(6): 601-607.
[15]	Xing-yu MA, Hao CHENG, Zhong-duo ZHANG, Ye-ming LI, Dong ZHAO. Research Progress of Metabolomics Techniques Combined with Machine Learning Algorithm in Wound Age Estimation [J]. Journal of Forensic Medicine, 2023, 39(6): 596-600.

Research Progress of MALDI-TOF-IMS in Biomedicine and Its Application Prospect in Forensic Sciences

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics